Structure of PDB 4c8b Chain B

Receptor sequence
>4c8bB (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
ALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLLLDSERKDV
LREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEY
PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIA
DFGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNP
LQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLK
CLIELEPVLRTFEEITFLEAVIQLKKTKLQS
3D structure
PDB4c8b Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.
ChainB
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R22 D146 K148 Q150 N151 D164 T189
Catalytic site (residue number reindexed from 1) R14 D133 K135 Q137 N138 D151 T154
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LI B A45 K47 E66 L79 T95 M98 L143 H144 I162 A163 D164 F165 A37 K39 E53 L66 T82 M85 L130 H131 I149 A150 D151 F152 BindingDB: IC50=1.000000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4c8b, PDBe:4c8b, PDBj:4c8b
PDBsum4c8b
PubMed26320862
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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