Structure of PDB 4c61 Chain B

Receptor sequence
>4c61B (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLHLRDFERE
IEILKSLQHDNIVKYKGVCLKLIMEYLPYGSLRDYLQAHAERIDHIKLLQ
YTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDK
EYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSK
SPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTEC
WNNNVNQRPSFRDLALRVDQIRDQMA
3D structure
PDB4c61 Discovery of 1-Methyl-1H-Imidazole Derivatives as Potent Jak2 Inhibitors.
ChainB
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D976 A978 R980 N981 D994 S1016
Catalytic site (residue number reindexed from 1) D121 A123 R125 N126 D139 S161
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LMM B L855 A880 M929 Y931 L932 P933 G935 N981 L983 G993 L13 A38 M74 Y76 L77 P78 G80 N126 L128 G138 MOAD: ic50=0.004uM
BindingDB: IC50=4.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4c61, PDBe:4c61, PDBj:4c61
PDBsum4c61
PubMed24359159
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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