Structure of PDB 4c5d Chain B

Receptor sequence
>4c5dB (length=145) Species: 9606 (Homo sapiens) [Search protein sequence]
LGSMSQSNRELVVDFLSYKLSQKGYSWSQMAAVKQALREAGDEFELRYRR
AFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVE
SVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNN
3D structure
PDB4c5d De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X0R B F97 Y101 R103 A104 Q111 F123 L130 R139 F143 F146 G147 M170 F44 Y48 R50 A51 Q58 F70 L77 R86 F90 F93 G94 M117 MOAD: Kd=4uM
PDBbind-CN: -logKd/Ki=5.40,Kd=4.0uM
BindingDB: IC50=13000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4c5d, PDBe:4c5d, PDBj:4c5d
PDBsum4c5d
PubMed24456288
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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