Structure of PDB 4c22 Chain B

Receptor sequence
>4c22B (length=604) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
HHHHSSGLVPRGSHMASIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKS
VADLISSTLKYPDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITV
TPCWCYGSETMDMSPDIPHAIWGFNGTERPGAVYLAAVLASHAQKGIPAF
GIYGRDVQEASDTDIPEDVKEKLLRYARAALATGLMRDTAYLSMGSVSMG
IGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRGIYDPEEFERALKWVKE
NVKEGFDHNREDLVLSREEKDRQWEFVIKMFMIGRDLMVGNPRLAELGFE
EEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFAT
ENDSLNGVSMLFNYLLTNTPQIFADVRTYWSPEAVKRVTGHTLEGRAAAG
FLHLINSGSCTLDGTGQATRDGKPIMKPFWELEESEVQAMLENTDFPPAN
REYFRGGGFSTRFLTKGDMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDV
HHTLDNRTDPGWPTTWFAPRLTGKGAFKSVYDVMNNWGANHGAITYGHIG
ADLITLASMLRIPVNMHNVPEEDIFRPKNWSLFGTEDLESADYRACQLLG
PLHK
3D structure
PDB4c22 Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus Pneumoniae.
ChainB
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E335 D359 H525
Catalytic site (residue number reindexed from 1) E351 D375 H541
Enzyme Commision number 5.3.1.25: L-fucose isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B E335 D359 H525 E351 D375 H541
BS02 FUC B W231 N235 G325 E418 W247 N251 G341 E434
BS03 CVU B Q300 E335 D359 S391 Y437 N524 H525 Q316 E351 D375 S407 Y453 N540 H541
Gene Ontology
Molecular Function
GO:0008736 L-fucose isomerase activity
GO:0008790 arabinose isomerase activity
GO:0016853 isomerase activity
GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0005996 monosaccharide metabolic process
GO:0006004 fucose metabolic process
GO:0019317 fucose catabolic process
GO:0019571 D-arabinose catabolic process
GO:0042355 L-fucose catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c22, PDBe:4c22, PDBj:4c22
PDBsum4c22
PubMed24333485
UniProtQ97N97|FUCI_STRPN L-fucose isomerase (Gene Name=fucI)

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