Structure of PDB 4c11 Chain B

Receptor sequence
>4c11B (length=603) Species: 12637 (Dengue virus) [Search protein sequence]
PETPNMDVIGERIKRIKEEHNSTWHYDDENPYKTWAYHGSYEVKATGSAS
SMINGVVKLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTPRPLP
GTRKVMEITAEWLWRTLGRNKRPRLCTREEFTKKVRTNAAMAANQWDSAK
AAVEDEEFWKLVDRERELHKLGKCGSCVYNMMASRAIWYMWLGVRYLEFE
ALGFLNEDHWFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAG
WDTRITEDDLHNEEKIIQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPTG
TVMDIISRKDQRGSGQVGTYGLNTFTNMEAQLVRQMEGEGVLTKADLENP
HLLEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGK
VRKDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIG
RARISQGAGWSLRETACLGKAYAQMWSLMYFHRRDLRLASNAICSAVPVH
WVPTSRTTWSIHAHHQWMTTEDMLTVWNRVWIEENPWMEDKTPVTTWENV
PYLGKREDQWCGSLIGLTSRATWAQNIPTAIQQVRSLIGNEEFLDYMPSM
KRF
3D structure
PDB4c11 A Crystal Structure of the Dengue Virus Ns5 Polymerase Delineates Inter-Domain Amino Acids Residues that Enhance its Thermostability and De Novo Initiation Activities.
ChainB
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H712 H714 C728 C847 H426 H428 C442 C561
BS02 ZN B E437 H441 C446 C449 E165 H169 C174 C177
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4c11, PDBe:4c11, PDBj:4c11
PDBsum4c11
PubMed24025331
UniProtQ6YMS4|POLG_DEN3S Genome polyprotein (Gene Name=pol)

[Back to BioLiP]