Structure of PDB 4c0s Chain B

Receptor sequence
>4c0sB (length=442) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
EKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGS
FKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMI
TGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVN
KMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLE
PSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDV
YKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEAL
PGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQI
SAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVE
MVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKS
3D structure
PDB4c0s Mammalian Translation Elongation Factor Eef1A2: X-Ray Structure and New Features of Gdp/GTP Exchange Mechanism in Higher Eukaryotes
ChainB
Resolution2.703 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D17 K20 S21 T72 H95
Catalytic site (residue number reindexed from 1) D14 K17 S18 T69 H92
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B D17 G19 K20 S21 T22 N153 K154 D156 S194 W196 D14 G16 K17 S18 T19 N150 K151 D153 S191 W193
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c0s, PDBe:4c0s, PDBj:4c0s
PDBsum4c0s
PubMed25326326
UniProtQ71V39|EF1A2_RABIT Elongation factor 1-alpha 2 (Gene Name=EEF1A2)

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