Structure of PDB 4bzc Chain B

Receptor sequence

>4bzcB (length=477) Species: 9606 (Homo sapiens)

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDC
HHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLH
RRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYT
KLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKR
YESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYC
KTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQW
CADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

• PDB: 4bzc Mechanism of Allosteric Activation of Samhd1 by Dgtp
• Chain: B
• Resolution: 2.88 Å

Enzymatic activity

• Enzyme Commision number: 3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	T8T	B	Q149 L150 R164 H210 H215 H233 K312 Y315 D319 R366 H370 Y374 Q375	Q37 L38 R52 H98 H103 H121 K192 Y195 D199 R246 H250 Y254 Q255
BS02	MN	B	H167 H206 D207 D311	H55 H94 D95 D191
BS03	T8T	B	V156 F157 R372 H376 K377	V44 F45 R252 H256 K257
BS04	T8T	B	Y155 V156 V378 R451	Y43 V44 V258 R331
BS05	T8T	B	V117 N119	V5 N7
BS06	T8T	B	K116 I118 D137 R145	K4 I6 D25 R33
BS07	T8T	B	R333 R352 K354 K523	R213 R232 K234 K401

External links

• PDB: RCSB:4bzc, PDBe:4bzc, PDBj:4bzc
• PDBsum: 4bzc
• PubMed: 24141705
• UniProt: Q9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)