Structure of PDB 4bz9 Chain B

Receptor sequence
>4bz9B (length=414) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDS
PSRMYEAVTAFHSTEYVDALKKLQMLHCELTADDELLMDSFSLNYDCPGF
PSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCYL
NDIVLAIHRLVSSQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASP
GFFPGTGTWNPIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGPILDSLN
IVIQPSYVVVQCGADCLATDPHRIFRLTNFYPNDSECSLSGYLYAIKKIL
SWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHSY
FSRYGPDFELDIDYFPHELDSIQKHHRRILEQLRNYADLNKLIYDYDQVY
QLYNLTGMGSLVPR
3D structure
PDB4bz9 Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D186 H188 D285 D173 H175 D265
BS02 KMY B K20 F21 D100 H141 H142 G150 D186 H188 F216 Y341 K19 F20 D96 H137 H138 G146 D173 H175 F203 Y314 BindingDB: IC50=4365nM
BS03 KMY B E131 K330 V331 P332 V361 E127 K303 V304 P305 V334 BindingDB: IC50=4365nM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006338 chromatin remodeling
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bz9, PDBe:4bz9, PDBj:4bz9
PDBsum4bz9
PubMed24086136
UniProtA5H660

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