Structure of PDB 4bv9 Chain B

Receptor sequence
>4bv9B (length=302) Species: 10090 (Mus musculus) [Search protein sequence]
RAPAFLSAEEVQDHLRSSSLLIPPLEAALANFSKGPDGGVMQPVRTVVPV
AKHRGFLGVMPAYSAAEDALTTKLVTFYEPSHQASVLLFDPSNGSLLAVM
DGNVITAKRTAAVSAIATKLLKPPGSDVLCILGAGVQAYSHYEIFTEQFS
FKEVRMWNRTRENAEKFASTVQGDVRVCSSVQEAVTGADVIITVTMATEP
ILFGEWVKPGAHINAVGASRPDWRELDDELMRQAVLYVDSREAALKESGD
VLLSGADIFAELGEVISGAKPAHCEKTTVFKSLGMAVEDLVAAKLVYDSW
SS
3D structure
PDB4bv9 Crystal Structure of Mouse Mu-Crystallin Complexed with Nadph and the T3 Thyroid Hormone
ChainB
Resolution2.193 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G60 S228
Catalytic site (residue number reindexed from 1) G58 S219
Enzyme Commision number 1.5.1.25: thiomorpholine-carboxylate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP B S90 H91 T115 R118 T119 G144 V145 Q146 N167 R168 T169 N172 V203 T204 M205 A206 V225 G226 S291 G293 S81 H82 T106 R109 T110 G135 V136 Q137 N158 R159 T160 N163 V194 T195 M196 A197 V216 G217 S282 G284 MOAD: Kd=1.7uM
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0016491 oxidoreductase activity
GO:0042562 hormone binding
GO:0042803 protein homodimerization activity
GO:0047127 thiomorpholine-carboxylate dehydrogenase activity
GO:0050661 NADP binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0007605 sensory perception of sound
GO:0042403 thyroid hormone metabolic process
GO:0070327 thyroid hormone transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:4bv9, PDBe:4bv9, PDBj:4bv9
PDBsum4bv9
PubMed24467707
UniProtO54983|CRYM_MOUSE Ketimine reductase mu-crystallin (Gene Name=Crym)

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