Structure of PDB 4btm Chain B

Receptor sequence
>4btmB (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
ADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQP
KQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRS
QPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYR
KCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHD
DLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHL
FLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKA
3D structure
PDB4btm X-Ray Structural Analysis of Tau-Tubulin Kinase 1 and its Interactions with Small Molecular Inhibitors.
ChainB
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F8E B G66 F69 I72 A85 C115 M131 Q132 L133 Q134 L199 D200 G22 F25 I28 A41 C71 M87 Q88 L89 Q90 L155 D156 BindingDB: Kd=4100nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4btm, PDBe:4btm, PDBj:4btm
PDBsum4btm
PubMed24039150
UniProtQ5TCY1|TTBK1_HUMAN Tau-tubulin kinase 1 (Gene Name=TTBK1)

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