Structure of PDB 4br3 Chain B

Receptor sequence
>4br3B (length=349) Species: 9606 (Homo sapiens) [Search protein sequence]
QPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGNMLFQCSLPDTTA
TLGDEPRKVLLRLYGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQF
IPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLK
EVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQ
EGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEK
YPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLE
VNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
3D structure
PDB4br3 Determination of Potential Scaffolds for Human Choline Kinase Alpha 1 by Chemical Deconvolution Studies
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.32: choline kinase.
2.7.1.82: ethanolamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U85 B G118 D306 Y333 Y354 W420 W423 I433 F435 Y440 G37 D198 Y225 Y246 W312 W315 I325 F327 Y332 MOAD: Kd=1.9uM
BS02 A4V B I116 L144 F208 I209 S211 R213 I329 I35 L60 F100 I101 S103 R105 I221
External links
PDB RCSB:4br3, PDBe:4br3, PDBj:4br3
PDBsum4br3
PubMed23813777
UniProtP35790|CHKA_HUMAN Choline kinase alpha (Gene Name=CHKA)

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