Structure of PDB 4bqv Chain B

Receptor sequence
>4bqvB (length=219) Species: 10090 (Mus musculus) [Search protein sequence]
TLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLS
AQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKAMDEK
CHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFY
KSGVYDDPSCTGNVNHGVLVVGYGTLDGKDYWLVKNSWGLNFGDQGYIRM
ARNNKNHCGIASYCSYPEI
3D structure
PDB4bqv Cathepsin S Nitrile Inhibitors
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q141 C147 H287 N307
Catalytic site (residue number reindexed from 1) Q20 C26 H166 N186
Enzyme Commision number 3.4.22.27: cathepsin S.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8PW B G145 C147 G191 G192 Y193 G260 V285 N286 H287 Y334 G24 C26 G70 G71 Y72 G139 V164 N165 H166 Y213
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4bqv, PDBe:4bqv, PDBj:4bqv
PDBsum4bqv
PubMed
UniProtO70370|CATS_MOUSE Cathepsin S (Gene Name=Ctss)

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