Structure of PDB 4blb Chain B

Receptor sequence

>4blbB (length=717) Species: 9606,83333 [Search protein sequence]

EGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAAT
GDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKL
IAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQE
PYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKH
MNADTDYSIAEHAFNHGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQ
PSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVA
LKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASG
RQTVDAALAAAQTNAAAPGLHAIYGECRRLYPDQPNPLQVTAIVKYDSFG
PDPLDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPS
GFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWH
SPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQW
NGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGS
NLSGVSAKCAWDSVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMA
ITFTGVEGAFATEEHAHGPWLQILLTEEFVEKMLEDLEDALPKEYSWPEK
KLKVSILPDVEHHHHHH

3D structure

PDB

4blb Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	Y487 F495 D499 H500 V501 S502 W503 H504 S607 G608 V609 S610 E641	Y483 F491 D495 H496 V497 S498 W499 H500 S603 G604 V605 S606 E621
BS02	GLC	B	D15 K16 E112 E154 W231	D11 K12 E108 E150 W227
BS03	GLC	B	W63 D66 R67 E154 Y156 W341	W59 D62 R63 E150 Y152 W337
BS04	ZN	B	H216 E222	H212 E218
BS05	ZN	B	H751 H753	H715 H717

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0015144	carbohydrate transmembrane transporter activity
GO:1901982	maltose binding

	Biological Process
GO:0006974	DNA damage response
GO:0008643	carbohydrate transport
GO:0015768	maltose transport
GO:0034219	carbohydrate transmembrane transport
GO:0034289	detection of maltose stimulus
GO:0042956	maltodextrin transmembrane transport
GO:0055085	transmembrane transport
GO:0060326	cell chemotaxis

	Cellular Component
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0043190	ATP-binding cassette (ABC) transporter complex
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060	maltose transport complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4blb, PDBe:4blb, PDBj:4blb
PDBsum	4blb
PubMed	24311597
UniProt	P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q9UMX1\|SUFU_HUMAN Suppressor of fused homolog (Gene Name=SUFU)

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