Structure of PDB 4bib Chain B

Receptor sequence
>4bibB (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERSQPLH
EEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPL
KDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDF
GTSKRLFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFY
ELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDL
LVDEFLKV
3D structure
PDB4bib Crystal Structures of Ask1-Inhibtor Complexes Provide a Platform for Structure Based Drug Design.
ChainB
Resolution2.43 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822 T842
Catalytic site (residue number reindexed from 1) D130 K132 D134 N135 D149 T160
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IEO B L686 A707 M754 Q756 V757 L810 D822 L17 A38 M81 Q83 V84 L137 D149 MOAD: ic50=0.63uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4bib, PDBe:4bib, PDBj:4bib
PDBsum4bib
PubMed23776076
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

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