Structure of PDB 4bf2 Chain B

Receptor sequence
>4bf2B (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
LEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPEREEIALH
KHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQT
IGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRL
ATGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQ
AAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFL
KV
3D structure
PDB4bf2 Crystal Structures of Ask1-Inhibtor Complexes Provide a Platform for Structure Based Drug Design.
ChainB
Resolution2.11 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822 T842
Catalytic site (residue number reindexed from 1) D124 K126 D128 N129 D143 T154
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU B L686 G689 V694 A707 M754 Q756 V757 D807 L810 S821 D822 L16 G19 V24 A37 M75 Q77 V78 D128 L131 S142 D143
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4bf2, PDBe:4bf2, PDBj:4bf2
PDBsum4bf2
PubMed23776076
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

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