Structure of PDB 4bcr Chain B

Receptor sequence
>4bcrB (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
EDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSPFVIHDMETLCMAEK
TLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDL
NDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFC
DIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE
GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTES
DAALHPLLQEIYRDM
3D structure
PDB4bcr Molecular Mechanism of Peroxisome Proliferator-Activated Receptor Alpha Activation by Wy14643: A New Mode of Ligand Recognition and Receptor Stabilization
ChainB
Resolution2.497 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WY1 B C276 T279 S280 Y314 F318 M355 K358 H440 C74 T77 S78 Y112 F116 M153 K156 H238 BindingDB: EC50=1600nM,Kd=0.360000nM,IC50=10110nM
BS02 WY1 B E251 R271 I272 H274 C275 E49 R69 I70 H72 C73 BindingDB: EC50=1600nM,Kd=0.360000nM,IC50=10110nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4bcr, PDBe:4bcr, PDBj:4bcr
PDBsum4bcr
PubMed23707408
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

[Back to BioLiP]