Structure of PDB 4b98 Chain B

Receptor sequence

>4b98B (length=440) Species: 287 (Pseudomonas aeruginosa)

PPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLS
GLWTCGAGHSRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLP
GELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNV
AGTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTGGVELANEL
LKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIF
DEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSEIYD
TFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELA
PHFEKGLHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQ
QGFYVRFGGDTLQFGPTFNARPEELDRLFDAVGEALNGIA

3D structure

• PDB: 4b98 Structural Studies with Pseudomonas and Chromobacterium [Omega]-Aminotransferases Provide Insights Into Their Differing Substrate Specificity.
• Chain: B
• Resolution: 1.65 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): F24 Y153 E226 D259 I262 K288 Q421
• Catalytic site (residue number reindexed from 1): F16 Y145 E218 D251 I254 K280 Q413
• Enzyme Commision number: 2.6.1.18: beta-alanine--pyruvate transaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PXG	B	F89 T327	F81 T319
BS02	PXG	B	W61 S119 G120 S121 Y153 H154 G155 E226 S231 D259 V261 I262 K288 R414 Q421	W53 S111 G112 S113 Y145 H146 G147 E218 S223 D251 V253 I254 K280 R406 Q413
BS03	PLP	B	V239 G240 Q243 F277 G278	V231 G232 Q235 F269 G270

Gene Ontology

Molecular Function

• GO:0004015 adenosylmethionine-8-amino-7-oxononanoate transaminase activity
• GO:0008483 transaminase activity
• GO:0016223 beta-alanine:pyruvate transaminase activity
• GO:0030170 pyridoxal phosphate binding

Biological Process

• GO:0009102 biotin biosynthetic process
• GO:0019483 beta-alanine biosynthetic process

External links

• PDB: RCSB:4b98, PDBe:4b98, PDBj:4b98
• PDBsum: 4b98
• PubMed: 23519665
• UniProt: Q9I700|BAUA_PSEAE Beta-alanine--pyruvate aminotransferase (Gene Name=bauA)