Structure of PDB 4b3g Chain B

Receptor sequence
>4b3gB (length=608) Species: 9606 (Homo sapiens) [Search protein sequence]
SAAVESFVTKQLDLLELERDAEVEERRSWLKELQSRGVCLLKLQVSSQRT
GLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVGLYDLATGILTRVTQKSV
TVAFDLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFG
RSAPSPASEIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTT
TVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKQRILRLGHPARLL
ESIQQHSLDAVLARSDSAQIVADIRKDIDQVRNEIKLLRKELKEREEAAM
LESLTSANVVLATNTGASADGPLKLLPESYFDVVVIDECAQALEASCWIP
LLKARKCILAGDHKQLPPTTVSHKAALAGLSLSLMERLAEEYGARVVRTL
TVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRDLPGVAATEETGVPL
LLVDTAGCGLFELEEEQSKGNPGEVRLVSLHIQALVDAGVPARDIAVVSP
YNLQVDLLRQSLVHRHPELEIKSVDGFQGREKEAVILSFVRSNRKGEVGF
LAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRTAF
EYLDDIVP
3D structure
PDB4b3g The Ighmbp2 Helicase Structure Reveals the Molecular Basis for Disease-Causing Mutations in Dmsa1.
ChainB
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B D87 I88 N141 V143 T144 P243 N245 R270 T351 T353 T407 H411 Q507 S508 Y541 N542 S563 D565 G589 F590 D80 I81 N119 V121 T122 P221 N223 R248 T313 T315 T369 H373 Q467 S468 Y501 N502 S523 D525 G549 F550
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:4b3g, PDBe:4b3g, PDBj:4b3g
PDBsum4b3g
PubMed22965130
UniProtP38935|SMBP2_HUMAN DNA-binding protein SMUBP-2 (Gene Name=IGHMBP2)

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