Structure of PDB 4av6 Chain B

Receptor sequence
>4av6B (length=642) Species: 2336 (Thermotoga maritima) [Search protein sequence]
ALFFLIPLVALGFAAANFAAVVRKISSYIRSGADSFLAHETKAIFKVAIV
IAILLMIFTTWQTGVAFLLGAVMSASAGIVGMKMATRANVRVAEAARTTK
LKVAYQGGSVMGLSVGGFALLGLVLVYLIFGQVDNLNIYTNWLGINFVPF
AMTVSGYALGCSIIAMFDRVGGGVYTKAADMAADLIADNVGDNVGDVAGL
GADLLESFVGAIVSSIILASYMFPIYVQKIGENLVHQVPKETIQALISYP
IFFALVGLGCSMLGILYVIVKKPSDNPQRELNISLWTSALLTVVLTAFLT
YFYLKDLQGAISPWFSAIIGIFSGILIGFWAEYYTSYRYKPTQFLGKSSI
EGTGMVISNGLSLGMKSVFPPTLTLVLGILFADYFAGLYGVAIAALGMLS
FVATSVSVDSYGPIADNAGGISEVRKITDHLDAVGNTTAAIGKGFAIGSA
IFAALSLFASYMFSQISPSDIGKPPSLVLLLNMLDARVIAGALLGAAITY
YFSGYLISAVTKAAMIEITSDNALKQMGYPAFIAILTPLVTGFLLGAEFV
GGVLIGTVLSGAMLAILTANSGGAWDNAKKYLEAGNLEGYGKGSEPHKAL
VIGDTVGDPLKDTVGPSLDILIKIMSVVSVIAVSIFKHVHLF
3D structure
PDB4av6 The Structure and Catalytic Cycle of a Sodium-Pumping Pyrophosphatase.
ChainB
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.3.1: Na(+)-exporting diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 B D202 D465 D660 D180 D416 D576
BS02 PO4 B D236 N492 D196 N436
BS03 MG B D202 D206 D180 D184
BS04 MG B D202 D688 D692 D180 D604 D608
BS05 MG B D232 D465 D192 D416
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphate phosphatase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0009678 diphosphate hydrolysis-driven proton transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0030955 potassium ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4av6, PDBe:4av6, PDBj:4av6
PDBsum4av6
PubMed22837527
UniProtQ9S5X0|HPPA_THEMA K(+)-stimulated pyrophosphate-energized sodium pump (Gene Name=hppA)

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