Structure of PDB 4ask Chain B

Receptor sequence
>4askB (length=423) Species: 9606 (Homo sapiens) [Search protein sequence]
KLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLF
STKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAK
YAQYQASSFQESLHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTST
GNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCE
WFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPG
DLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVK
SIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGK
KIAYQGRVKDEPAYYCNECDVEVFNILFVTSTYLVHCEGCARRRSAGLQG
VVVLEQYRTEELAQAYDAFTLAP
3D structure
PDB4ask A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response
ChainB
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1575 C1578 C1602 C1605 C366 C369 C387 C390
BS02 K0I B R1246 T1330 Y1379 K1381 T1387 P1388 H1390 E1392 N1393 N1400 N1480 R67 T121 Y170 K172 T178 P179 H181 E183 N184 N191 N271 BindingDB: IC50=16nM
BS03 CO B H1390 E1392 H181 E183
External links
PDB RCSB:4ask, PDBe:4ask, PDBj:4ask
PDBsum4ask
PubMed22842901
UniProtO15054|KDM6B_HUMAN Lysine-specific demethylase 6B (Gene Name=KDM6B)

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