Structure of PDB 4asj Chain B

Receptor sequence
>4asjB (length=291) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
RKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIREIL
IISTPQDTPRFQQLLGDGSNWGLDLQYAVQPSPDGLAQAFLIGESFIGND
LSALVLGDNLYYGHDFHELLGSASQRQTGASVFAYHVLDPERYGVVEFDQ
GGKAISLEEKPLEPKSNYAVTGLYFYDQQVVDIARDLKPSPRGELEITDV
NRAYLERGQLSVEIMGRGYAWLDTGTHDSLLEAGQFIATLENRQGLKVAC
PEEIAYRQKWIDAAQLEKLAAPLAKNGYGQYLKRLLTETVY
3D structure
PDB4asj Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.24: glucose-1-phosphate thymidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N6A B S41 L45 Y113 G115 F118 H119 V250 E255 S39 L43 Y111 G113 F116 H117 V248 E253 MOAD: Kd=0.028uM
BindingDB: IC50=73nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008879 glucose-1-phosphate thymidylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0009244 lipopolysaccharide core region biosynthetic process
GO:0019305 dTDP-rhamnose biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4asj, PDBe:4asj, PDBj:4asj
PDBsum4asj
PubMed23138692
UniProtQ9HU22

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