Structure of PDB 4ar8 Chain B

Receptor sequence
>4ar8B (length=389) Species: 1513 (Clostridium tetani) [Search protein sequence]
NKLIEEGKKHYLPKTYTFDNGKIIIKAGDKVEESKIQKLYWASKEVKSQF
HRIIGNDKPLEVGNADDILTIVIYNNPEEYKLNKTLYGYSVDNGGIYIEG
IGTFFTYERTPQESIYSLEELFRHEFTHYLQGRYLIPGLFNKGDFYKGNN
GRITWFEEGSAEFFAGSTRTSVLPRKSMVGGLSKNPKERFNADKLLHSKY
SDGWDFYKYGYAFSDYMYNNNKKLFSDLVSTMKNNDVKGYEALIEESSKD
SKINKDYEYHMENLVNNYDNYTIPLVSDDYMKQYDNKSLHEIKSDIEKAM
DVKNSQITKESSQYFDTYNLKATYTLSSNKGEISNWNYMNNKINEALNKL
DNLSWGGYKTVTAYFSNPRLNSNNEVVYDIVFHGLLSHN
3D structure
PDB4ar8 Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T.
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.3: microbial collagenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B G435 I437 Y438 S455 Y457 H465 E466 H469 E499 W545 Y548 G94 I96 Y97 S114 Y116 H124 E125 H128 E158 W204 Y207
BS02 ZN B H465 H469 E499 H124 H128 E158
BS03 CA B E440 G473 I477 G479 E99 G132 I136 G138
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ar8, PDBe:4ar8, PDBj:4ar8
PDBsum4ar8
PubMed23703618
UniProtQ899Y1|COLT_CLOTE Collagenase ColT (Gene Name=colT)

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