Structure of PDB 4aot Chain B

Receptor sequence
>4aotB (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
SMRKSREYEHVRRDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVI
ETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGA
VDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTL
EGDIRLADFGVSAKIGTPYWMAPEVVMPYDYKADIWSLGITLIEMAQIEP
PHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSA
AQLLEHPFVSSITSNKALRELVAEAKAEV
3D structure
PDB4aot Crystal Structure of Human Serine Threonine Kinase-10 (Lok) Bound to Gw830263A
ChainB
Resolution2.33 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D157 K159 G161 N162 D175 T195
Catalytic site (residue number reindexed from 1) D140 K142 G144 N145 D158 T167
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GW8 B A63 K65 I67 Y78 I108 I110 C113 L164 D175 F176 A46 K48 I50 Y61 I91 I93 C96 L147 D158 F159
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4aot, PDBe:4aot, PDBj:4aot
PDBsum4aot
PubMed
UniProtO94804|STK10_HUMAN Serine/threonine-protein kinase 10 (Gene Name=STK10)

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