Structure of PDB 4air Chain B

Receptor sequence
>4airB (length=304) Species: 5664 (Leishmania major) [Search protein sequence]
PFDKSRNVAQSIDQLIGQTPALYLNKLNNTKAKVVLKMECENPMASVKDR
LGFAIYDKAEKEGKLIPGKSVVVESSSGNTGVSLAHLGAIRGYKVIITMP
ESMSLERRCLLRIFGAEVILTPAALGMKGAVTMAKKIVTANPNAVLADQF
ATKYNALIHEETTGPEIWEQTNHNVDCFIAGVGTGGTLTGVARALKKMGS
HARIVAVEPMEDRSLIDEVFCVAGDDAIETALKLTRSDGVFCGFSGGANV
YAALKIAERPEMEGKTIVTIIPSFGERYLSTALYRSVRDEVSSLPVVDAS
ELQD
3D structure
PDB4air Structure of Leishmania Major Cysteine Synthase.
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K51 S274
Catalytic site (residue number reindexed from 1) K48 S245
Enzyme Commision number 2.5.1.47: cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K51 S79 S80 G81 N82 T83 R110 M130 G272 F273 S274 Y307 K48 S76 S77 G78 N79 T80 R107 M127 G243 F244 S245 Y278
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4air, PDBe:4air, PDBj:4air
PDBsum4air
PubMed22750854
UniProtQ4Q159

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