Structure of PDB 4af0 Chain B

Receptor sequence
>4af0B (length=395) Species: 235443 (Cryptococcus neoformans var. grubii H99) [Search protein sequence]
TNPNAPPRPDSLLNPSDALKHLEEYPRGDGLSLQELMDSRKNGGLTYNDF
LVLPGHINFPASDVSLQSKATKNIVLNTPFLSSPMDTVTEDRMAIALALH
GGLGIIHHNCSAEEQAAMVRRVKKYENYPYASKVPESKQLYCGAAIGTRP
GDKDRLKLLAEAGLDVVVLDSSQGNSVYQIEFIKWIKQTYPKIDVIAGNV
VTREQAAQLIAAGADGLRIGMGSGSICITQEVMAVGRPQGTAVYAVAEFA
SRFGIPCIADGGIGNIGHIAKALALGASAVMMGGLLAGTTESPGEYFYHE
GKRVKVYRGMGSIEAMEHTGLDNAATARYFSEADAVKVAQGVSGDVADKG
SINKFVPYLFTGLQHSLQDAGIKSVSELHSCARSGSLRFELRTAS
3D structure
PDB4af0 De Novo GTP Biosynthesis is Critical for Virulence of the Fungal Pathogen Cryptococcus Neoformans
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MOA B D288 S289 S290 N317 G338 M428 G429 Q470 D170 S171 S172 N199 G220 M310 G311 Q340 MOAD: Ki=198nM
BS02 IMP B S86 R336 G342 S343 I344 C345 D378 G380 G401 G402 Y425 G427 M428 G429 Q470 G471 S83 R218 G224 S225 I226 C227 D260 G262 G283 G284 Y307 G309 M310 G311 Q340 G341
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4af0, PDBe:4af0, PDBj:4af0
PDBsum4af0
PubMed23071437
UniProtE3P6S0

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