Structure of PDB 4a9n Chain B

Receptor sequence
>4a9nB (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
PGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPM
DMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEK
IFLQKVASMPQEEQE
3D structure
PDB4a9n Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides.
ChainB
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A9N B W97 P98 F99 L108 N156 M165 W26 P27 F28 L37 N85 M94 MOAD: ic50=1.5uM
External links
PDB RCSB:4a9n, PDBe:4a9n, PDBj:4a9n
PDBsum4a9n
PubMed22136469
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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