Structure of PDB 4a9m Chain B

Receptor sequence
>4a9mB (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
GRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMD
MGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKI
FLQKVASMPQEEQE
3D structure
PDB4a9m Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides.
ChainB
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P9M B W97 P98 F99 L108 N156 I162 W25 P26 F27 L36 N84 I90 MOAD: ic50=0.5uM
BindingDB: IC50=500nM
External links
PDB RCSB:4a9m, PDBe:4a9m, PDBj:4a9m
PDBsum4a9m
PubMed22136469
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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