Structure of PDB 4a9k Chain B

Receptor sequence
>4a9kB (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMD
LSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEV
FEQEIDPVMQSL
3D structure
PDB4a9k Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery.
ChainB
Resolution1.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYL B V1115 N1168 V1174 V31 N84 V90
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4a9k, PDBe:4a9k, PDBj:4a9k
PDBsum4a9k
PubMed22136404
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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