Structure of PDB 4a99 Chain B

Receptor sequence
>4a99B (length=368) Species: 818 (Bacteroides thetaiotaomicron) [Search protein sequence]
NLLSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLD
LHKGSGQEAMKKAGLLQTYYDLALPMGVNIADEKGNILSTKNVKPENRFD
NPEINRNDLRAILLNSLENDTVIWDRKLVMLEPGKKKWTLTFENKPSETA
DLVILANGGMSKVRKFVTDTEVEETGTFNIQADIHQPEINCPGFFQLCNG
NRLMASHQGNLLFANPNNNGALHFGISFKTPDEWTQVDFQNRNSVVDFLL
KEFSDWDERYKELIHTTLSFVGLATRIFPLEKPWKSKRPLPITMIGDAAH
LMPPFAGQGVNSGLVDALILSDNLADGKFNSIEEAVKNYEQQMFIYGKEA
QEESTQNEIEMFKPDFTF
3D structure
PDB4a99 Putative Dioxygen-Binding Sites and Recognition of Tigecycline and Minocycline in the Tetracycline-Degrading Monooxygenase Tetx
ChainB
Resolution2.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.231: tetracycline 11a-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G23 G25 P26 V27 E46 R47 L60 R117 L139 N168 G169 G310 D311 P318 G323 V324 G12 G14 P15 V16 E35 R36 L49 R106 L128 N157 G158 G296 D297 P304 G309 V310
BS02 MIY B R213 F224 N226 H234 P318 F319 A320 G321 R202 F213 N215 H223 P304 F305 A306 G307
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0071949 FAD binding
Biological Process
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4a99, PDBe:4a99, PDBj:4a99
PDBsum4a99
PubMed23999299
UniProtQ93L51|TETX_BACT4 Flavin-dependent monooxygenase (Gene Name=tetX2)

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