Structure of PDB 4a7w Chain B

Receptor sequence
>4a7wB (length=226) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
KNKRVLVKFSGEALAGDNQFGIDIHVLDHIAKEIKSLVENDIEVGIVIGG
GNIIIIRRTSGDYMGMLATVINAVAMQEALEHIGLDTRVQSAIEIKEICE
SYIYRKAIRHLEKGRVVIFGAGTGNPFFTTDTAATLRAIEIGSDLIIKAT
KVDGIYDKDPNKFKDAKKLDTLSYNDALIGDIEVMDDTAISLAKDNKLPI
VVCNMFKKGNLLQVIKHQQGVFSMVK
3D structure
PDB4a7w Structures of Helicobacter Pylori Uridylate Kinase: Insight Into Release of the Product Udp
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.22: UMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B R102 K110 E111 I112 C113 E114 H124 K127 R129 R88 K96 E97 I98 C99 E100 H110 K113 R115
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0009041 UMP/dUMP kinase activity
GO:0016301 kinase activity
GO:0033862 UMP kinase activity
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006225 UDP biosynthetic process
GO:0016310 phosphorylation
GO:0044210 'de novo' CTP biosynthetic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:4a7w, PDBe:4a7w, PDBj:4a7w
PDBsum4a7w
PubMed22751662
UniProtP56106|PYRH_HELPY Uridylate kinase (Gene Name=pyrH)

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