Structure of PDB 4a7b Chain B

Receptor sequence

>4a7bB (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]

YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNF
TRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDD
DETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFM
LPDDDVQGIQSLYGPG

3D structure

PDB

4a7b Lead Optimisation of Selective Non-Zinc Binding Inhibitors of Mmp13. Part 2.

Chain

Resolution

2.2 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H222 E223 H226 H232
Catalytic site (residue number reindexed from 1)	H119 E120 H123 H129
Enzyme Commision number	3.4.24.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	3W4	B	G183 L184 L185 H222 E223 G237 L239 F241 P242 I243 T245 F252	G80 L81 L82 H119 E120 G134 L136 F138 P139 I140 T142 F149
BS02	ZN	B	H222 H226 H232	H119 H123 H129
BS03	ZN	B	H172 D174 H187 H200	H69 D71 H84 H97
BS04	CA	B	D162 N194 G196 D198	D59 N91 G93 D95
BS05	CA	B	D179 G180 S182 L184 D202 E205	D76 G77 S79 L81 D99 E102

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4a7b, PDBe:4a7b, PDBj:4a7b
PDBsum	4a7b
PubMed	22153941
UniProt	P45452\|MMP13_HUMAN Collagenase 3 (Gene Name=MMP13)

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