Structure of PDB 4a5w Chain B

Receptor sequence
>4a5wB (length=871) Species: 9606 (Homo sapiens) [Search protein sequence]
CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETR
ECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPL
VAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDER
DCGRTKAVCTRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTV
KSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSLQGGSSFSVPI
FYSSKRSENINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLH
LSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSS
EELKNSGLTEEEAKHCVRIETHRCTTNKLSEKHEGSFIQGAEKSISLIRG
GEEKTFSEWLESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQE
YAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNA
VDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTF
SIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYL
VGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVL
TITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEK
DTLTKLKGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTS
PACKFLAEKCLNNQQLHFLHIGSCQDGRQLEWGLERTRLSSNSTKKESCG
YDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICE
VGTIRCANRKMEILHPGKCLA
3D structure
PDB4a5w Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B L156 N159 N162 D172 L135 N138 N141 D151
BS02 FUC B T38 C39 T17 C18
BS03 BMA B Q567 W568 R587 Q504 W505 R524
BS04 BMA B A516 D519 W571 A453 D456 W508
BS05 BMA B D25 W29 D4 W8
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006955 immune response
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0045087 innate immune response
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4a5w, PDBe:4a5w, PDBj:4a5w
PDBsum4a5w
PubMed22832194
UniProtP13671|CO6_HUMAN Complement component C6 (Gene Name=C6)

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