Structure of PDB 4a22 Chain B

Receptor sequence
>4a22B (length=329) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQ
FSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDK
LDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAA
AAAKIILEIEIGVVGGYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGV
YKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEE
ALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPR
SYLKKAEASMSQRVVQACNDLHCAGKSLT
3D structure
PDB4a22 Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D95 H96 H212 H252 N274
Catalytic site (residue number reindexed from 1) D94 H95 H198 H238 N260
Enzyme Commision number 4.1.2.13: fructose-bisphosphate aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TD4 B N27 S53 G55 D95 H96 H212 G213 G253 S255 N274 V275 D276 T277 N26 S52 G54 D94 H95 H198 G199 G239 S241 N260 V261 D262 T263 MOAD: Kd=6.8nM
PDBbind-CN: -logKd/Ki=8.49,IC50=3.2nM
BindingDB: IC50=3.2nM
BS02 ZN B H96 H212 H252 H95 H198 H238
Gene Ontology
Molecular Function
GO:0004332 fructose-bisphosphate aldolase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0016832 aldehyde-lyase activity
GO:0035375 zymogen binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4a22, PDBe:4a22, PDBj:4a22
PDBsum4a22
PubMed21949126
UniProtP9WQA3|ALF_MYCTU Fructose-bisphosphate aldolase (Gene Name=fba)

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