Structure of PDB 4a1v Chain B

Receptor sequence
>4a1vB (length=188) Species: 31647 (Hepatitis C virus subtype 1b) [Search protein sequence]
GSVVIVGRIILSGPITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVST
ATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAP
PGARSLTPCSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGP
LLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMR
3D structure
PDB4a1v High Affinity Peptide Inhibitors of the Hepatitis C Virus Ns3-4A Protease Refractory to Common Resistant Mutants.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H69 D93 G145 S147
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V-9 S7 Q9 S37 A39 T40 Q41 S42 H57 R109 L135 K136 G137 S139 F154 A156 A157 V158 C159 V6 S19 Q21 S49 A51 T52 Q53 S54 H69 R117 L143 K144 G145 S147 F162 A164 A165 V166 C167
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:4a1v, PDBe:4a1v, PDBj:4a1v
PDBsum4a1v
PubMed22965230
UniProtP26662|POLG_HCVJA Genome polyprotein

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