Structure of PDB 4a1t Chain B

Receptor sequence
>4a1tB (length=194) [Search protein sequence]
GSVVIVGRIILSGKGGPITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQV
VSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGW
QAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYL
KGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTM
3D structure
PDB4a1t High Affinity Peptide Inhibitors of the Hepatitis C Virus Ns3-4A Protease Refractory to Common Resistant Mutants.
ChainB
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H72 D96 G152 S154
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V-9 S7 Q9 S37 A39 T40 Q41 S42 F43 H57 R109 K136 G137 S139 F154 R155 A156 A157 V158 C159 V6 S22 Q24 S52 A54 T55 Q56 S57 F58 H72 R124 K151 G152 S154 F169 R170 A171 A172 V173 C174
BS02 ZN B C97 C99 C145 C112 C114 C160
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:4a1t, PDBe:4a1t, PDBj:4a1t
PDBsum4a1t
PubMed22965230
UniProtP26662|POLG_HCVJA Genome polyprotein

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