Structure of PDB 3zyu Chain B

Receptor sequence
>3zyuB (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB3zyu Inhibition of Bet Recruitment to Chromatin as an Effective Treatment for Mll-Fusion Leukaemia.
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1GH B P82 L92 I146 M149 P41 L51 I105 M108 MOAD: ic50=0.1uM
BindingDB: IC50=790nM,Ki=9.0nM,Kd=53nM
External links
PDB RCSB:3zyu, PDBe:3zyu, PDBj:3zyu
PDBsum3zyu
PubMed21964340
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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