Structure of PDB 3zvm Chain B

Receptor sequence
>3zvmB (length=379) Species: 10090 (Mus musculus) [Search protein sequence]
LGWESLKKLLVFTASGVKPQGKVAAFDLDGTLITTRSGKVFPTSPSDWRI
LYPEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEKLG
VPFQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAGRL
ANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPR
TISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHV
NRDTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVP
CRCFNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEG
FLEILEIPFRLQEHLDPALQRLYRQFSEG
3D structure
PDB3zvm The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.
ChainB
Resolution1.997 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.78: polynucleotide 5'-hydroxyl-kinase.
3.1.3.32: polynucleotide 3'-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B F184 N217 M219 G220 K225 R258 F305 F41 N74 M76 G77 K82 R115 F162
BS02 ADP B G374 G376 K377 S378 T379 N459 F462 R463 F502 Q505 H507 Y516 G231 G233 K234 S235 T236 N316 F319 R320 F359 Q362 H364 Y373
BS03 MG B D170 D172 D288 D27 D29 D145
BS04 MG B S378 D396 S235 D253
Gene Ontology
Molecular Function
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3zvm, PDBe:3zvm, PDBj:3zvm
PDBsum3zvm
PubMed22055185
UniProtQ9JLV6|PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase (Gene Name=Pnkp)

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