Structure of PDB 3zpr Chain B

Receptor sequence

>3zprB (length=298) Species: 9103 (Meleagris gallopavo)

GAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFIT
SLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIET
LCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHW
WRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVY
REAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVFTLCWLPFFLV
NIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLL

3D structure

• PDB: 3zpr Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Aryl Piperazine Leads Using Structure-Based Drug Design.
• Chain: B
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	B	E130 I161 T164	E99 I130 T133
BS02	Y01	B	R205 A206 I209	R174 A175 I178
BS03	Y01	B	L78 C85 R155 K159 W166	L47 C54 R124 K128 W135
BS04	3WC	B	D121 V122 V125 F201 S211 W303 F307 N310 N329 Y333	D90 V91 V94 F170 S180 W244 F248 N251 N270 Y274
BS05	2CV	B	D184 E185	D153 E154
BS06	2CV	B	Y231 L289 G293 M296	Y200 L230 G234 M237
BS07	2CV	B	R139 A142 E285 L289	R108 A111 E226 L230
BS08	2CV	B	L152 R157	L121 R126

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004935 adrenergic receptor activity
• GO:0004940 beta1-adrenergic receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
• GO:0045823 positive regulation of heart contraction

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3zpr, PDBe:3zpr, PDBj:3zpr
• PDBsum: 3zpr
• PubMed: 23517028
• UniProt: P07700|ADRB1_MELGA Beta-1 adrenergic receptor (Gene Name=ADRB1)