Structure of PDB 3zpi Chain B

Receptor sequence
>3zpiB (length=396) Species: 54571 (Streptomyces venezuelae) [Search protein sequence]
PPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRA
RAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREF
TMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELL
GVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGE
DLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLS
HPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPA
GDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLAR
LEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWRR
3D structure
PDB3zpi Recognition of Synthetic Substrates by P450 Pikc
ChainB
Resolution1.63 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D23 P47 F180 A243 E246 T247 T248 V290 C354 I355 G356 E363 I395
Catalytic site (residue number reindexed from 1) D12 P36 F169 A232 E235 T236 T237 V279 C343 I344 G345 E352 I384
Enzyme Commision number 1.14.15.33: pikromycin synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B M92 L93 H100 R104 F111 A243 G244 T247 T248 L251 T294 R296 A346 F347 H352 C354 I355 G356 A360 M81 L82 H89 R93 F100 A232 G233 T236 T237 L240 T283 R285 A335 F336 H341 C343 I344 G345 A349
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0033068 macrolide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3zpi, PDBe:3zpi, PDBj:3zpi
PDBsum3zpi
PubMed
UniProtO87605|PIKC_STRVZ Cytochrome P450 monooxygenase PikC (Gene Name=pikC)

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