Structure of PDB 3zml Chain B

Receptor sequence
>3zmlB (length=219) Species: 62324 (Anopheles funestus) [Search protein sequence]
KLVLYTLHLSPPCRAVELTAKALGLELEQKNINLLAGDHLTPEFMKLNPQ
HTIPVLDDDGTIITESHAIMIYLVTKYGKDDTLYPKDPVQQARVNAALHF
ESGVLFARMRFIFERILFYGKSDIPEDRIEYVQKSYRLLEDTLKDDFVAG
SKMTIADFSCISTISSIMGVVPLEQSEHPRIYEWIDRLKQLPYYEEANGG
GGTDLGKFVLAKKEENAKA
3D structure
PDB3zml A Single Mutation in the Gste2 Gene Allows Tracking of Metabolically-Based Insecticide Resistance in a Major Malaria Vector.
ChainB
Resolution1.639 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S12
Catalytic site (residue number reindexed from 1) S10
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH B S12 P14 H41 H53 T54 I55 E67 S68 F108 R112 S10 P12 H39 H51 T52 I53 E65 S66 F106 R110
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004364 glutathione transferase activity
GO:0016740 transferase activity
Biological Process
GO:0006749 glutathione metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3zml, PDBe:3zml, PDBj:3zml
PDBsum3zml
PubMed24565444
UniProtG0XSZ1

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