Structure of PDB 3zm9 Chain B

Receptor sequence
>3zm9B (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]
TRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATL
GDEPRKVLLRLYGAAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPS
RRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVL
RIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGN
ILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPF
FRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNR
FALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
3D structure
PDB3zm9 The Mechanism of Allosteric Coupling in Choline Kinase A1 Revealed by a Rationally Designed Inhibitor
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.32: choline kinase.
2.7.1.82: ethanolamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QMQ B F208 I209 R213 G310 I329 Y354 W420 W423 F435 F97 I98 R102 G199 I218 Y243 W309 W312 F324
External links
PDB RCSB:3zm9, PDBe:3zm9, PDBj:3zm9
PDBsum3zm9
PubMed23441033
UniProtP35790|CHKA_HUMAN Choline kinase alpha (Gene Name=CHKA)

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