Structure of PDB 3zlr Chain B

Receptor sequence
>3zlrB (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
SNRELVVDFLSYKLSQKGYSWSQMAAVKQALREAGDEFELRYRRAFSDLT
SQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEM
QVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAES
3D structure
PDB3zlr Structure-Guided Design of a Selective Bcl-Xl Inhibitor
ChainB
Resolution2.026 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X0B B E96 F97 Y101 R102 F105 S106 L108 E129 L130 G138 R139 F146 Y195 E37 F38 Y42 R43 F46 S47 L49 E70 L71 G79 R80 F87 Y136 MOAD: Kd=0.55nM
PDBbind-CN: -logKd/Ki=9.26,Kd=0.55nM
BindingDB: IC50=3.0nM,EC50=48nM,Ki=1.1nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3zlr, PDBe:3zlr, PDBj:3zlr
PDBsum3zlr
PubMed23603658
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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