Structure of PDB 3zhy Chain B

Receptor sequence
>3zhyB (length=370) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQ
TGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGL
RPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQC
LRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGPMNTLNSASLVN
KGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMK
LPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVA
GGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATV
DDVLDAQRWARERAQRAVSG
3D structure
PDB3zhy Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D151 E153 E222 D141 E143 E204
BS02 FM6 B S152 A176 S177 S213 N218 K219 S245 P265 M267 S142 A166 S167 S195 N200 K201 S227 P247 M249 BindingDB: Kd=210nM,IC50=320nM
BS03 NDP B G19 T21 G22 S23 I24 A46 G47 A49 H50 A69 A103 L104 A126 N127 K128 E129 D151 N209 M267 G9 T11 G12 S13 I14 A36 G37 A39 H40 A59 A93 L94 A116 N117 K118 E119 D141 N191 M249
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016491 oxidoreductase activity
GO:0030145 manganese ion binding
GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO:0046872 metal ion binding
GO:0050897 cobalt ion binding
GO:0070402 NADPH binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
GO:0051483 terpenoid biosynthetic process, mevalonate-independent
GO:0051484 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3zhy, PDBe:3zhy, PDBj:3zhy
PDBsum3zhy
PubMed23819803
UniProtP9WNS1|DXR_MYCTU 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Gene Name=dxr)

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