Structure of PDB 3zh8 Chain B

Receptor sequence
>3zh8B (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDID
WVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQ
RKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDY
GMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMM
AGRSPFDIVNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERL
GCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEQLTPDDDDI
VRKIDQSEFEGFEYINPLL
3D structure
PDB3zh8 Adenosine-Binding Motif Mimicry and Cellular Effects of a Thieno[2,3-D]Pyrimidine-Based Chemical Inhibitor of Atypical Protein Kinase C Isozymes.
ChainB
Resolution2.739 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D369 K371 N374 D387 T407
Catalytic site (residue number reindexed from 1) D131 K133 N136 D149 T169
Enzyme Commision number 2.7.11.13: protein kinase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C58 B I251 V259 Y325 V326 D330 L376 T386 D387 I13 V21 Y87 V88 D92 L138 T148 D149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007163 establishment or maintenance of cell polarity

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Molecular Function
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Biological Process
External links
PDB RCSB:3zh8, PDBe:3zh8, PDBj:3zh8
PDBsum3zh8
PubMed23418854
UniProtP41743|KPCI_HUMAN Protein kinase C iota type (Gene Name=PRKCI)

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