Structure of PDB 3zg0 Chain B

Receptor sequence

>3zg0B (length=635) Species: 158878 (Staphylococcus aureus subsp. aureus Mu50)

DKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEVEMTERPIKIYNSLGVK
DINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKEDGMWKLD
WDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPK
NVSKKDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSD
FAKKFHLTTNETESRNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDA
VIGKKGLEKLYDKKLQHEDGYRVTIVDDNSNTIAHTLIEKKKKDGKDIQL
TIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMS
NEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLDDKTSYK
IDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGS
KKFEKGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILI
NPVQILSIYSALENNGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQ
QVVNKTHKEDIYRSYANLIGKSGTAELKRQIGWFISYDKDNPNMMMAINV
KDVQDKGMASYNAKISGKVYDELYENGNKKYDIDE

3D structure

• PDB: 3zg0 How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function
• Chain: B
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	1W8	B	R298 N307 I309	R272 N281 I283
BS02	AI8	B	S403 Y446 S462 N464 G520 Q521 T582 H583 S598 T600 A601 E602 S643	S377 Y420 S436 N438 G494 Q495 T556 H557 S572 T574 A575 E576 S610
BS03	1W8	B	I144 N146 Y297	I118 N120 Y271
BS04	MUR	B	R151 T165 E239 S240 R241 V256 V277 H293	R125 T139 E213 S214 R215 V230 V251 H267

Gene Ontology

Molecular Function

• GO:0008658 penicillin binding
• GO:0071972 peptidoglycan L,D-transpeptidase activity

Biological Process

• GO:0046677 response to antibiotic
• GO:0071555 cell wall organization

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3zg0, PDBe:3zg0, PDBj:3zg0
• PDBsum: 3zg0
• PubMed: 24085846
• UniProt: A0A0H3JPA5