Structure of PDB 3zc6 Chain B

Receptor sequence
>3zc6B (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGP
DQQRDFQREIQILKALHSDFIVKYRGVSYGSLRLVMEYLPSGCLRDFLQR
HRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIA
DFGLAKLLPLDKDYYVVQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGSERPALSRLLELLEEGQRLPAPPACPAEVHE
LMKLCWAPSPQDRPSFSALGPQLDMLWS
3D structure
PDB3zc6 Strategic Use of Conformational Bias and Structure Based Design to Identify Potent Jak3 Inhibitors with Improved Selectivity Against the Jak Family and the Kinome.
ChainB
Resolution2.42 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) D133 A135 R137 N138 D151
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VFC B L828 G829 K830 G831 G834 V836 A853 K855 M902 E903 Y904 L905 G908 L956 L16 G17 K18 G19 G22 V24 A41 K43 M86 E87 Y88 L89 G92 L140 MOAD: ic50=0.6nM
BindingDB: IC50=0.600000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3zc6, PDBe:3zc6, PDBj:3zc6
PDBsum3zc6
PubMed23540648
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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