Structure of PDB 3wql Chain B

Receptor sequence
>3wqlB (length=286) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
NLVSEKEFLDLPLVSVAEIVRCRGPKVSVFPFDGTRRWFHLECNPQYDDY
QQAALRQSIRILKMLFEHGIETVISPIFSYIVQALEGMALLANDEEILSF
YKEHEVHVLFYGDYKKRLPSTAQGAAVVKSFDDLTISTSSNTEHRLCFGV
FGNDAAESVAQFSISWNETHGKPPTRREIIEGYYGEYVDKADMFIGFGRF
STFDFPLLSSGKTSLYFTVAPSYYMTETTLRRILYDHIYLRHFRPKPDYS
AMSADQLNVLRNRYRAQPDRVFGVGCVHDGIWFAEG
3D structure
PDB3wql Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis.
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D34 R38 Y51 Y90
Catalytic site (residue number reindexed from 1) D33 R37 Y50 Y80
Enzyme Commision number 2.5.1.153: adenosine tuberculosinyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D34 G206 F207 F213 D33 G196 F197 F203
BS02 MG B F207 R209 F197 R199
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0016791 phosphatase activity
GO:0062204 (13S)-vitexifolin A synthase activity
Biological Process
GO:0016102 diterpenoid biosynthetic process
GO:0035440 tuberculosinol biosynthetic process
GO:0052572 response to host immune response

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Molecular Function
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Biological Process
External links
PDB RCSB:3wql, PDBe:3wql, PDBj:3wql
PDBsum3wql
PubMed24475925
UniProtP9WJ61|TUBAT_MYCTU Tuberculosinyl adenosine transferase (Gene Name=Rv3378c)

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