Structure of PDB 3wf3 Chain B

Receptor sequence
>3wf3B (length=605) Species: 9606 (Homo sapiens) [Search protein sequence]
QRMFEIDYSRDSFLKDGQPFRYTSGSIHYSRVPRFYWKDRLLKMKMAGLN
AIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICA
EWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGG
PVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFL
KCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWG
QPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQP
TSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVT
LEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSN
PAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVE
NMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWG
HRNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYW
PARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRP
VIGSS
3D structure
PDB3wf3 Structural basis of pharmacological chaperoning for human beta-galactosidase
ChainB
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.23: beta-galactosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL B Y83 C127 A128 E129 E188 E268 Y270 W273 L274 Y306 Y333 Y55 C99 A100 E101 E160 E240 Y242 W245 L246 Y278 Y305
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004565 beta-galactosidase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016936 galactoside binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0019388 galactose catabolic process
GO:0030200 heparan sulfate proteoglycan catabolic process
GO:0042340 keratan sulfate catabolic process
GO:0046479 glycosphingolipid catabolic process
GO:0051413 response to cortisone
GO:1904016 response to Thyroglobulin triiodothyronine
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005773 vacuole
GO:0005794 Golgi apparatus
GO:0035578 azurophil granule lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:3wf3, PDBe:3wf3, PDBj:3wf3
PDBsum3wf3
PubMed
UniProtP16278|BGAL_HUMAN Beta-galactosidase (Gene Name=GLB1)

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