Structure of PDB 3w8z Chain B

Receptor sequence

>3w8zB (length=461) Species: 115828 (Streptomyces maritimus) [Search protein sequence]

QFPQLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARC
TSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIK
VSRRLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFG
WLSRKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVV
TAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLR
LAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKA
TLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPF
TQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWA
REGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTN
LFRLNQNIPPS

3D structure

PDB

3w8z Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement.

Chain

Resolution

1.8 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H78 S137 T245
Catalytic site (residue number reindexed from 1)	H77 S136 T244
Enzyme Commision number	1.13.12.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	W37 V73 R74 G75 G76 G77 H78 S79 M80 H83 S84 L94 G134 V135 V136 G140 G142 G143 L144 L146 F150 V200 V201 Y416 N418 F419 L455 N456	W36 V72 R73 G74 G75 G76 H77 S78 M79 H82 S83 L93 G133 V134 V135 G139 G141 G142 L143 L145 F149 V199 V200 Y415 N417 F418 L454 N455
BS02	HTK	B	V135 F150 G151 W152 Y249 E355 L357	V134 F149 G150 W151 Y248 E354 L356

Gene Ontology

	Molecular Function
GO:0016491	oxidoreductase activity
GO:0042802	identical protein binding
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

View graph for
Molecular Function

External links

PDB	RCSB:3w8z, PDBe:3w8z, PDBj:3w8z
PDBsum	3w8z
PubMed	24162851
UniProt	Q9KHK2

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