Structure of PDB 3w3n Chain B

Receptor sequence
>3w3nB (length=749) Species: 9606 (Homo sapiens) [Search protein sequence]
RSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNE
SFQGLQNLTKINLNHNPNVGLNITDGAFLNLKNLRELLLEDNQLPQIPSG
LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIE
DGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFK
GLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLN
LSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILD
LSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQL
PNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLFEFDPHSNFY
HFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNA
QVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYF
RIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGN
RLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTE
LHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLL
LSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLE
LHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSL
3D structure
PDB3w3n Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B D462 H464 D394 H396
BS02 RX8 B F346 Y348 Y353 V378 F405 F303 Y305 Y310 V335 F362 BindingDB: EC50=4500nM
BS03 RX8 B D543 D545 G572 T574 D475 D477 G504 T506 BindingDB: EC50=4500nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3w3n, PDBe:3w3n, PDBj:3w3n
PDBsum3w3n
PubMed23520111
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

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